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Psilocybin and psilocin are two closely related compounds with psychedelic properties found in certain species of mushrooms, commonly referred to as psychedelic mushrooms or magic mushrooms. These compounds have been used for centuries in traditional medicine and ceremonial uses, particularly in tribal societies of the Americas, where they played a significant role in the rituals and ceremonies of the Aztecs and Mayans.

The mechanisms of action are still unknown, but considerable breakthroughs have been achieved to understand their interactions with the body. Psilocybin and psilocin are a type of psychoactive agents, similar to MDMA.

When psilocybin is ingested, it is rapidly metabolized into psilocin by an enzyme called monoamine oxidase. Psilocin then connects with the 5-HT2A receptor, leading to altered perception. This activation leads to the release of neurotransmitters, such as dopamine and norepinephrine.

The effects of these compounds on brain function are best explained by their influence on neural activity. One such system is the salience network, involved in stimulus detection and evaluation.

Psilocybin and psilocybe truffles psilocin have been shown to reduce activity in the DMN, leading to a decrease in self-centered thinking.

Another key process affected is the emotional regulation network, involved in emotional processing.

In addition to their influence on brain function, psilocybin and psilocin have been found to have significant effects on mood and behavior.

Studies have reported significant improvements in mood.

The therapeutic potential of psilocybin and psilocin has been recognized.

More studies are required to uncover the mechanisms of action.

However, available research indicates that psilocybin and psilocin may have significant therapeutic benefits.